Gefährliche Aliskiren-Kombinationen

Ressourceneffiziente Hardware-Software-Kombinationen für Kryptographie mit elliptischen Kurven

Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy

Hypertension is a major risk factor for the development of cardiovascular and renal disease. The incidence of hypertension is increasing globally and the rate of blood pressure control remains inadequate. Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in volume regulation and maintenance of blood pressure. Pathological activation of RAAS results in chronic hypertension and con...

▼Aliskiren for hypertension in adults

High blood pressure is a major risk factor for cardiovascular disease worldwide.1 Drug treatments include those that target the renin-angiotensin system, a key hormone cascade in the regulation of blood pressure. One of these is ▼aliskiren (Rasilez – Novartis), which belongs to a new class of drugs, direct renin inhibitors.2 Here we assess its place in managing adults with hypertension. BNF 2.5...

Combination of aliskiren and amlodipine in hypertension

Hypertension frequently resists control with monotherapy, requiring two or more antihypertensive agents in combination. Many antihypertensive fixed-dose combinations (FDCs) combine drugs with different, but complementary, mechanisms of action to improve overall efficacy and tolerability. Antihypertensive FDCs may provide significant advantages over high-dose monotherapy, such as improved effica...

Aliskiren, ALTITUDE, and the implications for ATMOSPHERE

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK; Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; University of Bergen, Bergen, Norway; University of California, San Francisco, San Francisco, C...